الفهرس 
Preparation and characterization of different pharmaceutical formulations of baclofen via skin route Thesis
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Abstract
The aim of the present study was to formulate topical gel containing baclofen niosomes. Baclofen is a direct agonist at GAPAB receptors with an anti-inflammatory effect. Baclofen has narrow therapeutic index and many gastrointestinal side effects. The current market products of baclofen are intrathecal injection and oral tablets which cause many problems after their administration. Thus, niosomal formulation as carriers for the topical delivery of baclofen will improve its efficacy, as anti-inflammatory. This was achieved through the encapsulation of baclofen in niosomes aiming at prolonging its action and avoiding most of its side effects. The baclofen niosomes were prepared by altering the ratios between various non-ionic surfactants (Span 60, 40), cholesterol and charge inducing agents using thin film hydration method, the prepared niosomal formulations were evaluated for their encapsulation efficiency and high drug EE% were found, and characterized by transmission electron microscopy, differential scanning calorimetry, particle size analysis, zeta potential analysis and in vitro release performance