الفهرس 
Title : Pharmaceutical Study on Certain Ocular Drug Delivery Systems Using Model Drug
ContentsOnly 14 pages are availabe for public view
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Abstract
Conjunctivitis is characterized by inflammation and swelling of the conjunctival tissue, accompanied by engorgement of the blood vessels, ocular discharge, and pain. Many subjects are affected by conjunctivitis worldwide, and it is one of the most frequent reasons to general medical and ophthalmology clinics.
The second generation of topical antihistamines plays a curial role and is considered the most frequent recent therapeutic guideline and blocking histamine receptors, thus reducing the inflammation of the conjunctiva.
Loratadine is a second-generation, tricyclic antihistamine (piperidine derivative) with selective antagonistic properties to peripheral histamine H1-receptors, LORA belongs to class II of the BCS, additionally, LORA is a weak base its pKa value as 4.85–6.00. The solubility of bases decreases with high ocular pH, therefore the solubility invariably leads to poor absorption and low concentrations of the drug in the ocular tissues
Nevertheless, conventional topical administration is exceptionally ineffective, with typically <5% of applied drug achieving target tissues due to ocular anatomy and physiological obstacles.
Lipid nanoparticles are an inventive drug delivery system that permits to overcome the physiological difficulties of the eye Nanostructured Lipid Carriers (NLCs) are considered the modified generation of Solid Lipid Nanoparticles SLN, NLCs are better than other conventional nanocarriers in enhancing the solubility, drug loading of lipophilic drugs, and trans-corneal penetrability, which affords a property of controlled and prolonged release of drug. It is fabricated with biodegradable lipids and offers superior solubility and bioavailability.
Muco-adhesion Ocugel drug delivery systems gained their muco-adhesion properties from a muco-adhesion polymer which has a comparatively high viscosity, thus, extending retention time in the cornea and conjunctival sac, and sustaining drug release despite the nasolacrimal draining reflex and ocular blinking.