الفهرس 
Title : Stability of Dental Implants Placed in Healed Bony Sites of Hyperlipidemic Patients: A Case Series
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Abstract
The effect of elevated levels of serum fats -hyperlipidemia- on the long-term implant stability and
bone quality has been heavily examined in animal-model studies. This human-based case series aimed
at clinically and radiographically evaluating implant stability and the changes in bone density in patients
with high lipid profile. Twelve participants, each had a single healed bony site which indicated for
implantation together with high serum fasting (Low-density lipoprotein) LDL level (≥160 mg/dl) were
included in this study. The differences between the clinical implant stability values (ISQ) which were
measured using the Resonance Frequency Analysis (RFA) method, and the radiographic CBCT changes
were recorded at baseline and six months post-implant insertion. In addition, the Patient-reported
outcomes (PROs) including pain, swelling as well as patient satisfaction were evaluated via NRS, VRS
based questionnaires. All patients showed successful osseointegration after six months. There was a
significant increase of implant stability after 6 months from (65.92 پ} 6.39 ISQ) to (74.42پ}6.20 ISQ)
(p<0.001). The mean linear and volumetric radiographic crestal bone level at the baseline (238.49پ}55.62
mm2) were significantly higher than that found after 6 months (204.94پ}72.95 mm2) (p=0.018).
Regarding bone density, there was no significant difference between values found at baseline
(586.20پ}239.92 HU) and after 6 months (657.90پ}162.14 HU) (p=0.121). However, based on the results
obtained and the limitations of this very first clinical study on the correlation between dental implant
stability and hyperlipidemia, authors found that hyperlipidemia alone is not considered a major risk factor
for dental implant stability.