الفهرس 
Effect of Gamma radiation and Camel’s Milk Antibodies on Hepatocellular Carcinoma in Experimental Animals
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Abstract
The current study revealed the promising therapeutic benefits of camel milk
antibodies in conjunction with low dose radiation on N-nitrosodiethylamine-
induced hepatocellular carcinoma in rats. Antibodies IgG were purified from
camel milk and showed a significant cytotoxicity on HepG2 cells. Multi-stage
hepatocarcinogenesis was induced in animal model using N-nitrosodiethylamine
and carbon tetrachloride. Subsequently, tumor-bearing rats were treated with IgG
and/or exposed to a single dose of gamma rays (0.25 Gy). Treatment with camel
antibodies and/or gamma radiation reduced liver enzymes activities, alpha
fetoprotein levels, enhanced liver histology, attenuated the inflammation and
oxidative stress as well as enhanced antioxidant status. Also, it reduced hepatic
protein expression of Inducible nitric oxide synthase and down-regulated nuclear
factor-erythroid 2-related factor2 and Glutathione-S-transferase placental gene
expression.