الفهرس | Only 14 pages are availabe for public view |
Abstract This thesis is concerned with the quantitative analysis of some drugs in multi-component pharmaceutical formulations used to alleviate pain, namely; paracetamol co-formulated with caffeine, ergotamine tartrate, and metoclopramide hydrochloride, and paracetamol, aspirin co-formulated with diphenhydramine hydrochloride. Also, the analytical methods involved paracetamol impurities, namely; p-aminophenol and p-nitrophenol, as well as theophylline as caffeine impurity, and salicylic acid as aspirin impurity. This study aims to design simple, robust, accurate, eco-friendly, and economic analytical approaches for analysis of the cited drugs in their pure powdered forms, combined pharmaceutical formulations in presence of their degradation products or impurities and/or in different biological matrices. Chapter I General Introduction and Literature Review. Chapter II Greenness Profile Assessment of selective Liquid chromatographic Methods for Determination of a Quaternary Anti-migraine Combination Along with Three of Their Related Official Impurities. Chapter III A Reliable Electrochemical Sensor Based on Functionalized Magnetite Nanoparticles for Over-the-counter Allergy Medication Abuse Sensing in Biological Fluids. Chapter IV Sustainable Liquid chromatographic Determination and Purity Assessment of a Possible Add-on Triple-Action Over-the-counter Pharmaceutical Combination in COVID-19. Chapter V Resolution of Spectrally Overlapping signals of Paracetamol, Aspirin, and Diphenhydramine in their combined Over-the-counter Pharmaceutical Formulation: Application to Content Uniformity Testing. Chapter VI General Conclusion This thesis is divided into six chapters and ended with a list of references, and a summary in Arabic. The six chapters are: |