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Abstract
Preoperative diagnosis of solid pseudo-papillary neoplasm of the pancreas (SPN) remains dif{uFB01}cult and optimal surgical management for SPN has yet to be fully de{uFB01}ned. Our aim was to summarize our experience with the diagnosis and surgical treatment of solid pseudo-papillary neoplasm (SPN) of the pancreas to provide a reference for the management of this rare condition. We collected and analyzed retrospective data on the clinical presentation, laboratory investigations, radiologic imaging, pathology and operative details of patients with SPNs who underwent surgery at the National cancer institute between January 2003 and December 2013. In all, 22of 23 patients were women, and the mean age of all patients was 28 ± 11years. The most common clinical presentation was vague abdominal mass associated with vague abdominal pain. Abdominal imaging showed solid or solid cystic masses in the pancreas, mostly in the tail of the gland. All patients were treated surgically. There were no postoperative deaths. All patients were followed-up for a median follow up period 12 months with a range of 6 -144 months and a mean overall survival (OS) of 116 ± 13 months. Curative resection was performed in 22 patients (95.7%), with a mean disease free-survival time (DFS) of 109 ± 17 months. Only 2 (8.6 %) patients had local recurrence, one of them had soft tissue nodules at the operative bed after 6 months of the surgery proved to be malignant with PET CT and the decision follow up CT after 6 months and the second patient had local recurrence with multiple liver metastasis after 6 years and was managed by the best supportive care. Three (13 %) patients died, 2 (8.6%) of them had a tail lesion and died after 7 and 8 months respectively following complete resection without obvious causes which might be metabolic causes or sepsis, while the third patient had a tail lesion and died from local recurrence and liver metastasis 6 years following radical resection