الفهرس Only 14 pages are availabe for public view
 |  | from | 297 |  |  |
| | | from | 297 | | |
Abstract
Peptic ulcer disease (PUD) is the most prevalent gastro intestinal disorder. The pathophysiology of PUD involves an imbalance between offensive (acid, pepsin and H. pylori) and defensive factors (mucin, prostaglandin, bicarbonate, nitric oxide and growth factors).Some psychological conditions like anxiety, stress, surgical shock, burns and trauma also stimulate gastric acid secretion and leads to ulcer. Free radicals, oxidants, physical, chemical factors are also involved in the pathogenesis of PUD. A number of drugs are used in the treatment of ulcers but its clinical evaluation shows the incidence of relapses, side effects with interaction of other drugs. Currently there are different classes of drugs like proton pump inhibitors, H2 receptor blockers, antibiotics and anti-acids are available for treatment of peptic ulcer but all these drugs have side effects and limitations