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العنوان
Progress toward the synthesis of specific inhibitors of the large amino acid transporter (LAT1) and inhibitors of the mitotic kinesin Eg5 as anti-cancer agents /
الناشر
Rasha Ahmed Mahmoud Hassan ,
المؤلف
Rasha Ahmed Mahmoud Hassan
هيئة الاعداد
باحث / Rasha Ahmed Mahmoud Hassan
مشرف / Samir Botros Salib
مشرف / Douglass Fleming Taber
مشرف / Azza Taher Shalaby
تاريخ النشر
2015
عدد الصفحات
239 P. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الصيدلة ، علم السموم والصيدلانيات (المتنوعة)
تاريخ الإجازة
11/5/2015
مكان الإجازة
جامعة القاهرة - كلية الصيدلة - Organic Chemistry
الفهرس
Only 14 pages are availabe for public view

from 135

from 135

Abstract

This thesis composed three chapters. The first chapter covers the progress toward the synthesis of Brasilicardin A (BraA) which is a specific inhibitor of the large amino acid transporter (LAT1). It includes four sections. The first section is an introduction explains the importance of LAT1 inhibitors as anti-cancer agents and a review of the synthetic trials of BraA and its skeleton. The second section clarifies the objective of the work and the schemes adopted for the preparation of the target compounds. The third section deals with the theoretical discussion of the experimental work for the preparation of the target compounds. The fourth section explains the experimental procedures used for the synthesis of the target compounds, as well as the physical properties and detailed data obtained from spectral analysis