الفهرس | Only 14 pages are availabe for public view |
Abstract Cholangiocarcinoma is the most common biliary malignancy and the second most common hepatic malignancy after HCC. It accounts for approximately 10–25% of all hepatobiliary malignancies. CCA accounts for about 20% of the deaths from hepatobiliary cancers, which cause 13% of the total cancer mortality worldwide. Epidemiologic studies suggest that its incidence has been increasing in Western countries during the last decades. To identify specific genes involved in the cancer development is crucial for novel therapeutics development, cancer prevention and early diagnosis. In recent years, polymorphisms which have been investigated in cell proliferation and apoptosis of tumors become the new hot spots in tumor molecular genetic research. |