الفهرس | Only 14 pages are availabe for public view |
Abstract Part 1: The cyclocondensation reaction of aldehydes with dimedone and bis(6-aminopyrimidin4-one) in acetic acid led to the formation of the corresponding bis(pyrimido[4,5-b]quinoline-4,6- diones) which are known as bis(sulfanediyl)bis(tetrahydro-5-deazaflavin) analogs in a single step. Also, bis(pyrimido[4,5-b]quinoline-4,6-diones) which are linked to naphthyl core via phenoxymethyl linkage is prepared. The interactions of the synthesized compounds with DNA and bovine serum albumin (BSA) were studied. Gel electrophoresis assay used to show the capability of the compounds to photocleave the supercoiled plasmid DNA (pBR322 plasmid DNA) in UV-A (365 nm). Besides, the most photocleavable compound, 14b, exhibits good binding affinities toward DNA and BSA using UV-Vis spectral method. Molecular docking methods were also used for modeling the binding of the 14b to DNA and BSA and good agreements were found between the experimental and theoretical results. Part 2: A simple, and efficient procedure has been developed for the synthesis of a new series of 1,4-dihydropyridin-3,5-dicarbonitriles, hexahydroacridine-1,8-diones, 7,14-dihydro-6H,8Hdichromeno[4,3-b:3’,4’-e]pyridine-6,8-diones, and 1,4,7,8-tetrahydrodipyrazolo[3,4-b:4’,3’- e]pyridines which are linked to phenoxy-N-arylacetamide utilizing 2-(4-formylphenoxy)-Narylacetamides as precursors. |