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Abstract
Different methods for the determination of some drugs used in the treatment of colon diseases, in bulk and dosage forms have been introduced in this thesis. The cited drugs are (balsalazide disodium, chlordiazepoxide, mebeverine hydrochloride, mesalazine, olsalazine sodium, and otilonium bromide). The chromatographic part includes a method for simultaneous determination of three commonly prescribed drugs used for treatment of inflammatory bowel diseases and was appled in ternary mixtures and dosage forms. Also, it involved simultaneous determination of olsalazine sodium and its degradation product 5-aminosalicylic acid (mesalazine) and was applied in binary mixtures and dosage form. Finally in this part, an HPLC method was introduced for the simultaneous determination of otilonium bromide and its degradation product 4- aminobenzioc acid and was applied in dosage form. On the other hand, spectrophotometric part includes simultaneous spectrophotometric determination of mebeverine hydrochloride and chlordiazepoxide in bulk and pharmaceutical dosage form using three chemometric techniques, classical least square(CLS), principal component regression (PCR) and partial least squares (PLS). Also, it involved simultaneous determination spectrophotometric determination of otilonium bromide with its degradation products 4- aminobenzoic acid and salicylic acid using CLS, PCR and PLS chemometric techniques