الفهرس 
Title : Immunohistochemical study of survivin expression in colonic adenoma and adenocarcinoma
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Abstract
Background: The antiapoptotic protein, survivin has been demonstrated to play an important role in colorectal carcinogenesis. In colorectal cancer (C.R.C.), survivin over expression has been demonstrated to occur in precursor lesions such as adenoma, suggesting that survivin up regulation is an early event in tumorigenesis. Aim of Work: This work aimed to examine differential immunohistochemical (I.H.C.) expression of survivin in normal colonic mucosa, high and low grades of colonic adenoma and colonic adenocarcinoma as well as its correlation with the clinicopathological features of such lesions. Methods: This study consisted of 50 cases of colonic tissue sections, selected as 10 cases of normal colonic tissue and 20 cases for each of colonic adenoma and C.R.C. I.H.C. reactions were carried out by using survivin monoclonal antibody. A total score of survivin expression was obtained by multiplying the score of staining intensity and score of percentage of positively stained cells to obtain score of more than 3 as (positive) or less than 3 as (negative). Results: I.H.C. staining of survivin in the selected cases displayed a heterogeneous expression pattern, with differences in the distribution and intensity of positivity. According to survivin score, 22 cases (44%) were negative, 28 cases (46%) were positive. There was statistically significant correlation detected regarding differential survivin expression in normal colonic mucosa (10%), colonic adenoma (45%) and colonic adenocarcinoma 90%, P value =0.000