الفهرس 
Measurement of serum levels of Pentraxin 3, Interleukin 10 and Interleukin 18 in patients with chronic renal failure on regular hemodialysis
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Abstract
Chronic kidney disease is characterized by an irreversible deterioration of renal function that gradually progresses to end stage renal disease (ESRD). Its incidence in children has become increased. The aim of this study was to measure the serum levels of pentraxin 3 (PTX-3), interleukin 10 (IL10) and interleukin 18 (IL18), as a reflection of inflammatory status, in children with end stage renal disease on regular hemo-dialysis and to show the effect of hemo-dialysis on these inflammatory markers and cytokines that were measured pre and post dialysis.The present study included sixity patients, they were divided into 2 groups, group (A) included thirty patients with end stage renal disease (ESRD), attended regular sessions of hemo-dialysis at nephrology department, Paediatric hospital, Cairo university. group (B) included fifteen patients with chronic kidney disease (CKD stage III and IV), attended regular follow up at nephrology clinic and they were on conservative therapy only and not dialysis, in addition to fifteen healthy age and sex matched children who served as controls.The mean for age of hemo-dialysis (HD) patients (group A) was 11.93±3.79 years compared 8.46±3.63 years for conservative patients (group B) and the mean of duration of dialysis was 6.03±2.46 years. group A (HD) patients had a significantly higher post dialysis levels of serum PTX-3 and IL18 than pre dialysis with significant P value of (0.044, 0.001) respectively and there was no significant difference observed as regard IL10 between pre and post dialysis.HD patients had a significantly higher levels of serum PTX-3 and IL18 than conservative patients (group B) with significant P value of (0.006, 0.01) respectively. PTX-3 and IL18 were higher in patients who dialyzed via central catheter than A.V fistula with significant P value of (0.04, 0.002) respectively while IL10 was significantly lower in patients dialyzed via central catheter than A.V fistula with P value of 0.03