الفهرس 
The impact of treatment modalities on the outcome in patients with breast cancer younger than or equal to 40 years of age
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Abstract
This is a retrospective cohort study of the results of different treatment methods of breast cancer patients younger than or equal to 40 years treated at NCI-Cairo university between (2005 - 2013) locoregional treatment was either with breast conservative treatment (BCT), modified radical mastectomy (M), or modified radical mastectomy followed by radiotherapy (MRM+RT). The total number is 655 patients from which 221 patients (33.7) received BCT, 92 patients (14%) underwent MRM and 342 patients (52.2%) underwent MRM followed by RT. Median follow up for all patients was 67 months to detect the impact of these different treatment modalities on the LRR, DM and OS. There was no statistically significant difference between the different treatment modalities on the LRR as the LRR after BCT was 9.5% (21 patients from 221), 10.9% after MRM (10 patients from 92) and 7% after MRM+RT (24 patients from 342), P value 0.381. Higher incidence of LRR was detected in the patients who have negative hormone receptors (10% vs. 5.6% for patients with positive hormone receptors ). Patients who underwent MRM without receiving PORT and who had negative hormone receptors showed higher incidence of LRR (17.8%) compared to patients who underwent MRM then PORT (7.3%) and to those who received BCT (11.6%). Molecular subtypes was available for 176 patients, from which 9 % developed LRR and the highest incidence was for TNBC patients 7 patients out of 55