الفهرس 
Effect of work environment air pollution in major industrial facilities on Egyptian workers
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Abstract
Background: Metals are the major occupational hazards in foundry workers, and exposure may result in DNA damage, lipid peroxidation, liver and kidney toxicity through oxidative stress. This study aimed to investigate the heavy exposure to those metals and possible health effect among foundry workers. Results: All air measurements were below the maximum allowable limits (MAL) according to international regulations and Egyptian Environmental Law 4 except for aluminum and lead levels were above MAL according to ACGIH. Blood metal analysis revealed significantly elevated levels of metals in workers for B-Al, B-Cd, B-Cu and B-Pb. Moreover, the level of MDA and 8-OHdG were found to be highly significantly increased (P<0.0001), while the mean level of GSH was found to be highly significantly reduced in exposed workers as compared to control group (P<0.0001). No statistically significant differences were found between the two groups in regards to CA and DNA fragmentation. No association between the indicators of oxidative damage and hOGG1 genotype was found (Ý=0.064; 0.131; -0.077; p>0.05 respectively). The mean sera of ALT, AST, Þ-GT, ALP, LDH and bile acids were significantly elevated while the levels of albumin and total protein were significantly decreased in exposed group. The AUC and sensitivity of BT score were 91.2% and 78.2 %, respectively. The mean concentrations of urea and uric acid were significantly elevated in exposed group, but there were no statistically significant difference in the creatinine and MDRD-GFR levels between the two studied group