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العنوان
Urinary N- acetyl - βeta -D- Glucosaminidase (NAG) in Children with Epilepsy Treated with Sodium Valproate Monotherapy /
المؤلف
Abdalla, Heba Refat.
هيئة الاعداد
باحث / هبه رفعت عبد الله
مشرف / سحر عبد العظيم عبد العزيز
مشرف / هشام احمد السروجى
مشرف / هالة ابراهيم هنطش
الموضوع
Pediatric.
تاريخ النشر
2022.
عدد الصفحات
202 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
طب الأطفال ، الفترة المحيطة بالولادة وصحة الطفل
تاريخ الإجازة
30/10/2022
مكان الإجازة
جامعة طنطا - كلية الطب - Pediatric
الفهرس
Only 14 pages are availabe for public view

from 251

from 251

Abstract

Epilepsy is one of the most common neurologic conditions with an incidence of approximately 50 new cases per year per 100,000 populations. About 1% of the population suffers from epilepsy and about one-third of patients have refractory epilepsy. Approximately 75% of epilepsy begins during childhood, reflecting the heightened susceptibility of the developing brain to seizures. Antiepileptic drugs (AED) are the mainstay for treatment of epilepsy with about 70% of children achieving good control with medications alone. AED do not cure epilepsy or treat the reason why epilepsy has started. The aim of treatment is to stop seizures from happening and improve quality of life of children. According to the American Academy of Neurology, AED side effects may range from 7% to 31%, but are mostly mild and reversible. AED can impact cognition and learning either positively or negatively. where medications successfully control the seizures, they are reducing the abnormal activity in the brain which can affect learning, therefore improving the child‟s ability to learn. With chronic use, many AED carry a side effect of renal tubular dysfunction and fanconi syndrome. Once administered of AED, monitoring of serum medication levels is recommended to establish a therapeutic baseline and assess for toxicity. With checking of serum level of drug, complete blood count, a comprehensive metabolic panel, liver and renal function tests should routinely occurred.