الفهرس 
Anatomy of the BrainOnly 14 pages are availabe for public view
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Abstract
Diffusion tensor imaging is a noninvasive magnetic resonance imaging technique that identify sensitive biomarkers of Alzheimer’s disease While anatomical MRI is the main structural neuroimaging method used in most AD studies and clinical trials, DTI is sensitive to microscopic white matter changes not detectable with standard MRI, offering additional markers of neurodegeneration. The aim of this study is to detect early white matter microstructural changes in patients with mild cognitive impairment & early Alzheimer disease using diffusion tensor imaging (DTI). The study included twenty patients with MCI and early AD as well as their ages ranged between 59 and 75 years old. Ten age matched control group were also included in this study which was carried out during a period of 12 months from June 2021 to June 2022. MRIs were performed by usage of 1.5 Tesla Technique was performed using a standard 1.5 Tesla unit (GE HealthCare, Sigma HDX., W). In MRI unit, Radiology department, Tanta University Hospital with the use of the head coil. Non contrast High-resolution 3D T1 weighted spoiled gradient echo pulse sequence was acquired & Diffusion Tensor imaging in 40 directions were done in all the studied cases (Exclusion criteria were Patients with a relevant neurological disease (stroke, tumor, etc.), Cardiac patients with arrhythmia, Patients who had general contraindications for MRI such as those who had electrically or magnetically activated implants (cochlear implants) and Claustrophobic patients.