الفهرس 
CEREBRAL SMALL VESSEL DISEASEOnly 14 pages are availabe for public view
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Abstract
Cerebral small vessel disease (CSVD) causes great disability at increasing age such as cognitive impairment, gait and sphincteric problems affecting a person’s quality of life. That is why it’s important to detect and manage early. The aim of this study is to investigate certain micro-RNA in Egyptian patients with CSVD.
Methods: Thirty patients with CSVD were compared to thirty controls undergoing assessment for cognitive, gait and sphincteric control together with MRI brain and blood sampling for miRNA (miR-409-3p, miR-502-3p, miR-486-5p and miR-451a). Results: No difference regarding age, gender or risk factors, yet MiRNA-451a was up-regulated in cases with a median fold change of 3.4 in comparison to healthy controls. Conclusion: The studied microRNA can may have a role in pathophysiology of CSVD.