الفهرس 
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Abstract
The present study was undertaken to evaluate the potential protection afforded by Ginseng extract (GIN) against hepatic and testicular toxicity induced by dexamethasone (DEX) in adult male rats. The experimental rats were divided into four groups, The first group was served as control, the second group was given GIN extract orally at a dose of 200 mg/kg b.wt/day using the gastric tube for 10 days. The third group was injected i.p. once/day DEX at a dose of 7 mg/kg b.wt for 10 days. The fourth group was orally administered GIN (200 mg/kg bw) concurrently with DEX injection (7mg/kg bw) for 10 days. Injection of rats with DEX caused biochemical, histological and immunohistochemical adverse alternations in both liver and testis, DEX disturb oxidative stress and antioxidant markers (MDA, GSH, SOD and CAT), as well as cause loss of normal structure of both hepatic and testicular tissues with significant histopathological alternations and immunohistochemical changes including increase in Bax protein expression accompanied with decrease in Bcl-2 protein expression in both liver and testis causing apoptosis. Treatment with GIN extract restores the antioxidant status, scavenge free radicals and ROS causing attenuation in oxidative stress, apoptosis and structural and functional adverse changes induced by DEX in both liver and testis, and this implies that GIN has a protective impact against DEX-induced hepatic and testicular toxicity.