الفهرس 
Impact of schistosomiasis on the performance of real time elastography for staging of fibrosis in chronic HCV patient
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Abstract
Background: Hepatitis C virus (HCV) and Schistosomiasis are highly endemic in Egypt and co-infection is frequently encountered. Such co-infection is responsible for leading to a more severe liver disease. Noninvasive assessment of liver histology has been the focus of research for many years. Aim of the work:To assess the impact of Schistosomiasis on the performance of real time elastography versus fibroscan for staging of fibrosis in chronic HCV patient. Patients and methods: This is a prospective study conducted on 101 chronic HCV patients. Theywere categorized into two groups. group A; 50 HCV patients with positive antischistosomal antibody and group B; 51 HCV patients with negative antischistosomal antibody. They weresubjected to baseline pretreatment laboratory tests, including LFTs, KFTs, CBC, PC., INR , random blood sugar, and serology for HBsAg. They were examined by both noninvasive measures; Transient Elastography (Fibroscan) and Real-time Tissue Elastography (Hitachi- RTE) for the assessment and staging of liver fibrosis, and finally they performed liver biopsy. Results: no statistically significant difference in the fibroscan stiffness and real time elastography results between both groups in all stages of liver fibrosis (by biopsy).Cut off values for liver fibrosis index LFI by RTE for the prediction of significant fibrosis (F {u2265}2) in group A and group B were 2.66 and 2.835 respectively and for advanced liver fibrosis (F{u2265}3) in group A and group B were 2.750 and 2.935, respectively, while for cirrhosis (F = 4) in group A and group B were 2.70 and 4.94, respectively. Conclusion:Exposure to schistosomiasis has no effect on the performance of real time elastographyor fibroscanfor staging of liver fibrosis in chronic HCV patient