الفهرس | Only 14 pages are availabe for public view |
Abstract Camel antibodies is unusual simplified non canonical antibodies (HCAb) which devoid of CH1 domain and light chain which gave it great chance for different application in diagnosis and treatment. In this study, immunization of Egyptian camel with tetanus toxoid for studying the structure and features of camel nanobodies, the serum were collected and purified and found that the main antibody in serum of camel is HCAb (75-80kDa) which appeared by SDS-PAGE. The prophylactic and therapeutic effects of nanobodies were tested in groups of Mice injected with tetanus toxin. The camel antibodies can enter the nerve cell and neutralize the toxin and relieve the signs of toxicity |