الفهرس 
Recipient IL28B variant as predictor of new onset diabetes mellitus in liver transplant patients with chronic hepatitis C
list of contentOnly 14 pages are availabe for public view
 |  | from | 120 |  |  |
| | | from | 120 | | |
Abstract
Background: New onset diabetes after liver transplantation (NODAT) is increasingly recognized as a complication that affects the quality of life. In addition to well known risk factors for diabetes in such patients, little is known regarding the genetic predisposition for this condition. Aim of the study: To study the association of IL28B polymorphism with occurrence of new onset DM after liver transplantation in HCV patients. Methods: A prospective cohort study. Fifty non-diabetic LDLT recipients were recruited from the liver transplantation unit at Elmanial, Cairo- University Hospital. FBS was done at 0, 3 and 12 months; HBA1c was done after 6 months. IL28B rs12979860 polymorphism was done to all patients. Results: According to FBS after 3months and HBA1C, 20 patients developed diabetes, 21 patients prediabetes and 9 remained normal. IL28B CT genotype was 74%, CC 24% and TT 2%. G. Univariate regression showed that the CT genotype was significantly associated with higher blood glucose at 0 months (coefficient ± SE, 64±4.7; P<0.001), 3 months (coefficient ±SE, 58±4.0; P<0.001) and 12 months (coefficient ±SE, 57±3.2; P<0.001), and with development of diabetes and prediabetes after LDLT. (coefficient ±SE, 0.6±0.06; P<0.001). Conclusion: IL28B polymorphism is significantly associated with new onset diabetes after LDLT. CT genotype may represent a marker to identify high risk recipients