الفهرس 
Evaluation of the role of Multi-drug resistance-1 gene polymorphisms in diagnosis of nephrotic syndrome in Egyptian children
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Abstract
Background: Nephrotic Syndrome (NS) is a primary immune disease associated with various genetic backgrounds and polymorphisms including multi drug resistance 1 (MDR1) gene which may influence the prognosis and steroid responsiveness in children with idiopathic nephrotic syndrome (INS). Objectives: To evaluate the association of MDR-1 gene (c.G2677T: rs2032582 and c.C3435T: rs1045642) polymorphisms in childhood nephrotic syndrome and whether they influence steroid response. Subjects and Methods: A case control study of 100 participants: 60 children with nephrotic syndrome (35 with steroid sensitive nephrotic syndrome (SSNS), 25 with steroid resistant nephrotic syndrome (SRNS)) and 40 age and sex matched healthy control children. All subjects were analyzed for MDR1 c.G2677T: rs2032582 and MDR1 c.C3435T: rs1045642 polymorphisms using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Results: On comparing either the INS and control groups or SSNS and SRNS groups, the results showed that there were no statistically significant differences between the INS and the control groups nor between SSNS and SRNS. Conclusion: We conclude that there is no association between frequency distribution of MDR1 c.G2677T and MDR1 c.C3435T genotypes and development of nephrotic syndrome