الفهرس 
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Abstract
Introduction
The kidney is important organ that manage numerous essential functions in the body. Kidneys maintain chemical balance and remove metabolic wastes from the body Calbreath, (1992) and Ajith et al., (2007). Therefore, the integrity of this organ is the primary target of drug induced damage. Drug-induced nephrotoxicity is a frequent adverse event as statistics indicate acute or chronic kidney disease and increased healthcare spending. It has a high morbidity and mortality in 40-70% of kidney injuries and accounts for 66% of cases of renal failure in the elderly WHO, (2018).
Nephrotoxicity is the most common kidney problem that occurs when the body is exposed to a drug or toxin. When kidney damage occurs, the body unable to get rid of excess urine and wastes from the body and blood electrolytes. Konam and Yalamuri, (2014).
Cisplatin is a clinically advanced and highly effective anticancer drug used in the treatment, it has only limited use in clinical practice due to its severe adverse effects, particularly nephrotoxicity; 20%–35% of patients develop acute kidney injury (AKI) after Cisplatin administration. Recent in vitro and in vivo studies show that numerous natural products (flavonoids, saponins, alkaloids, polysaccharides, phenylpropanoids, etc.) have specific antioxidant, anti-inflammatory, and anti-apoptotic properties that regulate the pathways associated with Cisplatin-induced kidney damage ( Fang et al., 2021).