الفهرس | Only 14 pages are availabe for public view |
Abstract Abstract Salt ingestion has been linked to kidney disease via hemodynamic (increased introglomerular pressure) and non- hemodynamic mechanisms (increased oxidative stress), independent of blood pressure. The aim of the present study was to compare the effect of rock salt (Halite) to refined salt in different concentrations on chronic renal failure rats. Thirty adult male Sprague-Dawley rats which weighing (170+5g) were divided randomly into two main groups as follow: the first group (-ve control= 5 rats) was fed on basal diet. The second group (25 rats) were fed on 14 % casein diet containing 0.7% adenine for 4 weeks to induce chronic kidney disease (CKD), then divided into 5 subgroups from group 2 to group 6. Subgroup 2 (+ve control) fed on basal diet. Subgroup 3 and 4 fed on basal diet supplemented with 4% and 8% of refined salt, respectively. Subgroup 5 and 6 fed on basal diet supplemented with 4% and 8% of rock salt, respectively. At the end of the experimental period (4 weeks), rats fasted overnight before sacrificing and blood samples were taken from each rat and was centrifuged to obtain serum which collected to determine kidney functions. The results showed that serum concentrations of creatinine, urea, uric acid, sodium and potassium were significantly elevated (P<0.05) by adenine administration (positive control) compared to negative control, in contrast, serum total protein, albumin and globulin were significantly reduced (P<0.05). Also, it was indicated that rock salt administration recorded the best changes for these parameters in CKD rats compared to refined salt. It be concluded that restriction of sodium intake is an important preventive and therapeutic measure in patients with chronic renal diseases or at risk of renal damage such as hypertensive. So, it be recommended to use rock salt instead of refined salt and further studies are required to elucidate beneficial effect and the mechanism of how |