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Abstract Introduction: Polycystic ovary syndrome (PCOS) is a common disorder affecting up to 15% of women in the reproductive age. Prior studies suggest that PCOS can be associated with mood and other mental disorders. Aim: The aim of the study is to estimate the prevalence of depression and anxiety in adolescent females with polycystic ovary syndrome and community adolescent females{u2019} sample and to examine factors associated with depression, anxiety. Methods: The study was conducted on 84 girls with PCO and 47girls from community underwent a structured interview using pre-designed questionnaire covering sociodemographic characters, medical data, anthropometric measures general examination for acne and hirsutism staging and 7 questions of GAD 7 questionnaire for anxiety and 9 questions of PHQ 9 for depression screening. Results: Among PCO sample and community sample there was high prevalence of depression (89% vs 93%) and anxiety (32% vs 61%) respectively. There was significant correlation between degree of anxiety and severity of acne (p=0.005) (rs=0.353) and between degree of anxiety and severity of hirsutism(p> 0.001) (rs=0.468) among PCO sample. Also, there was significant association between BMI with depression among PCO sample (P=0.013) |