الفهرس 
Title ; Association between long noncoding RNA taurine up regulated gene 1(TUG1) and microRNA-377 in vitiligo
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Abstract
Background: Vitiligo is the commonest hypopigmented skin disorder. Taurine upregulated gene1(TUG1), one of Long noncoding RNAs (LncRNA) that plays a role in melanogenesis. microRNA-377 (miRNA-377) is a conserved non-coding RNA that regulates angiogenesis and promotes oxidative stress. Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily. PPARÞ activators stimulate melanogenesis. Interleukin-17(IL17) has been implicated in the pathogenesis of several immunological diseases. Aim: This work aimed to detect the expression levels of TUG1, miRNA-377, PPARÞ and IL-17 among vitiligo subjects and to investigate their possible role in the pathogenesis of vitiligo. Methods: This study was conducted on 30 healthy control and 30 vitiligo patients. TUG1 and miRNA-377 were detected in serum by real- time-PCR, Also PPARÞ and IL-17 were assessed in tissue by Real-time PCR. Results: TUG1and PPARÞ level was significantly down regulated in vitiligo group compared to control group, on the other hand miRNA-377 and IL-17 was significantly up regulated in vitiligo group compared to control group