الفهرس 
Title : Evaluation of biologic biomarkers in patients with Oral Lichen Planus (Diagnostic and Immunologic study)
ContentsOnly 14 pages are availabe for public view
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Abstract
Background: Oral lichen planus is one of the most common oral mucosal lesions. It is a T-cell mediated autoimmune disease in which the auto-cytotoxic CD8+ T-cells trigger apoptosis of the basal cells of the oral epithelium . The most potent functions of TGF-Ý are the growth inhibition and apoptosis induction of many cell types. It can suppress immune response by induction of the apoptosis of B-cells and repressing T-cell proliferation. Vascular endothelial growth factor is a key regulator of vasculogenesis and angiogenesis. A positive feedback loop, in which an inflammatory state promotes angiogenesis which in turn facilitates chronic inflammation, has been found. Tumor necrosis factor-Ü is one of the most abundant early mediators in inflammation. It is a key regulator of innate & adaptive immune responses . Oral lichen planus lesions may present as asymptomatic white striae bilaterally, predominantly on the buccal mucosa. There are three clinical patterns of OLP that may coexist. The diagnosis of OLP can be made based on the history and clinical findings but sometimes histopathologic examination may be mandatory. Serum and salivary biomarkers can be obtained easier than tissues, allow repeated measurement and less expensive. Aim of the present study: The aim of the present study was to compare the levels of TNF-Ü, VEGF and TGF-Ý in serum and saliva between patients with OLP and normal individuals. Also to probe whether serum and saliva can be used as noninvasive diagnostic technique .Subjects and methods The current study was carried out on 23 patients diagnosed as OLP patients and other 23 healthy controls. OLP diagnosis was confirmed histopathologically. Serum and salivary blood samples were collected from OLP patients and healthy individuals for TGF-Ý, VEGF &TNF-Ü analysis