الفهرس 
Title : Assessment of ventricular function In asthmatic children
ContentOnly 14 pages are availabe for public view
 |  | from | 165 |  |  |
| | | from | 165 | | |
Abstract
Background: Asthma is the most chronic inflammatory disorder of the airways in children which may lead to pulmonary hypertension, right ventricular (RV) dysfunction, and finally cor pulmonale later in life. We aimed to investigate both left (LV) and right (RV) ventricular function in asthmatic children as detected by conventional, tissue doppler and speckle tracking echocardiography. Patients and methods: This is a case control study that was conducted on thirty pediatric patients with asthma and twenty seven healthy children . Pulmonary function tests, conventional, tissue doppler and speckle tracking echocardiography examinations were performed on all children. Results: Median age was 9.5 year with range (8-11) year in asthmatic group and 9 year with range (8-11) year in the control group (P = 0.728). The mean value of RVEDD was significantly higher among asthmatic patients compared to control subjects with P value < 0.05. RV diastolic function was significantly decreased in the asthma group (early diastolic velocity of the tricuspid lateral annulus (E’) was significantly lower in Asthmatic patients with p =0.04). the right ventricular myocardial performance index (MPI) of the asthmatic subjects was significantly higher compared to control subjects (p=0.001). Pulmonary artery pressure (PAP), pulmonary Velocity time integral (P VTI), pulmonary vascular resistance (PVR), pulmonary preejection period (PEP) and PEP/ET were statistically significant between case and control groups with (P=0.035, P=0.004, p<0.00021, P<0.001, p=0.002 respectively). Peak expiratory flow (PEF) was positively correlated with right ventricle early diastolic velocity of the tricuspid lateral annulus (RV-E’) (p<0.05) and PVTI (p<0.05). PEF was negatively correlated with RVDD, RV-MPI, PVR, and PEP with p=0.005, p<0.05, p<0.0001, p=0.001 respectively