الفهرس | Only 14 pages are availabe for public view |
Abstract In a search for new cytotoxic agents with improved activity and selectivity, certain new aminopyridines, pyridones and tyrphostin AG17 analogs bearing a sulfonamide moiety have been synthesized. All the newly synthesized compounds were subjected to in vitro cytotoxic screening against human breast carcinoma cell line (MCF-7). Further biological evaluation of the most cytotoxic compounds against cyclin dependent kinase-2 (CDK2) was done. The promising compounds were selected to be evaluated again for their in vitro cytotoxic activity in combination with Þ-radiation. The newly synthesized compounds were docked inside the active site of CDK2 (cyclin-dependent kinase-2) enzyme in an attempt to predict their anticancer mechanism of action |