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Abstract
Background and Goal of Study: Postdural puncture headache (PDPH) is a common complication after spinal anesthesia. The role of pregabalin and hydrocortisone in treatment of PDPH is unclear. The aim of this work is to assess and compare the efficacy of both drugs in severe cases of PDPH after spinal anesthesia for elective cesarean section. Materials and methods: 30 patient with PDPH with VAS score {u2265} 5 after spinal anesthesia for elective cesarean section were included in the study. Patients were divided into three groups: Control group (group C): received conventional treatment in the form of good oral hydration, 500 mg of acetaminophen plus 65 mg of caffeine oral tablets thrice daily, 3 cups of coffee daily, 50 mg of diclofenac potassium oral tablets twice daily and recumbent positioning for 48 hours. Pregabalin group (group P): received the conventional treatment plus 100 mg of pregabalin oral tablet every 8 hours for 48 hours. Hydrocortisone group (group H): received the conventional treatment plus 100 mg of hydrocortisone IV every 8 hours for 48 hours. The three groups were compared regarding the headache intensity using visual analogue scale