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Abstract Total knee arthroplasty has become one of the most commonly performed orthopaedic operations for the treatment of end-stage knee arthritis. Perioperative blood loss is a significant concern for patients undergoing TKA, controlling blood loss during and after surgery is important to improve the patient outcome. Tranexamic acid is one of the several modalities employed to minimize blood loss in patients undergoing TKA. Tranexamic acid present in several forms IV, IM and oral. The most important finding of the present study was that intraarticular retrograde injection of TA via the drain at the end of the operation and then clamping the drain for 1 h effectively reduced postoperative blood loss and thus the need for blood transfusion after TKA. This method is simple, easy to perform, suitable for these patients, and understandable for clinicians. Regarding the perioperative blood loss management in TKR, intra-articular tranexamic acid (IA-TXA) application has recently become a popular method due to its excellent efficacy for reducing post operative bleeding and transfusion requiremen. We found also a significant correlation between body mass index, diabetes mellitus, hypertension and postoperative bleeding. |