الفهرس | Only 14 pages are availabe for public view |
Abstract Borderline personality disorder (BPD) is a chronic psychiatric disorder characterized by pervasive patterns of affective instability, selfimage disturbances, instability of interpersonal relationships, marked impulsivity, and suicidal behavior (suicidal ideation and attempt) causing significant impairment and distress in individual‘s life. Individuals with BPD have an underlying vulnerability to emotional hyperarousal states due to abnormalities in neurobiological systems sub-serving emotional regulation and stress responsibility. They also have an underlying vulnerability to social and interpersonal stressors due to abnormalities in neurobiological systems mediating social cognition, attachment, and social reward (Kulacaoglu and Kose, 2018). It is most frequently associated with mood disorders, anxiety disorders, eating disorders and substance misuse. Post-traumatic stress disorder is also common but not universal in patients with BPD. Severe and stable functional impairment is characteristic, as well as a high risk of suicide with a mortality rate between 8% and 10%, which is 50-times higher than in the general population (Leichsenring et al, 2011). In epidemiological studies of adults in the USA, the median prevalence for BPD was 1.4% of the general population. Not only are there significant health care costs associated with the disorder, but also impairment in social and occupational functioning results in unemployment and foregone earnings. Thus, the costs of this disorder are multifaceted, including the personal, familial, economic, and societal (Meehan et al, 2018). |