الفهرس 
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Abstract
In this study 79 samples (38 colectomy from patients who were known to have colorectal adenocarcinoma and 41 from non-colorectal adenocarcinoma including gastric, intestinal, pancreatic, liver, lung, ovarian and intestinal biopsies and specimens) were studied for SATB2 immunohistochemical expression.
All CRC cases showed positive SATB2 expression score. More than half of them demonstrated score +3, while (92.7%) of non-colorectal adenocarcinoma cases were negative for SATB2. Only 3 cases (intestinal, pancreatic and gastric biopsies) were positive for SATB2.There was a highly statistical difference between SATB2 expression score in CRC cases and non-colorectal adenocarcinoma group p value <0. 001.
Median age of cases was about 53 years. Males were slightly predominant 52.6%, about two third of CRC cases were found in right side and more than half of CRC cases 65.8% had ≥ 5cm in diameter.
About three quarters of CRC cases were adenocarcinoma NOS with score+3. A high statistically significant difference in SATB2 expression score in different pathological types with the highest score in adenocarcinoma NOS tumors p value equal 0.002.
Three quarters of our CRC cases had low grade. There was a highly statistically significant relation between SATB2 expression score and different tumor grades with most of score +3 had low grade tumors, while all score +1 cases were high grade, p value <0.001. A statistically significant correlation (-0.663) between the tumor grade and SATB2 expression score.
More than half of cases were grade PDC G1. A highly statistically significant difference in SATB2 expression score in different PDC grades with the highest score in grade 1 and lowest score in grade 3, p value <0.001. More than half of our studied CRC cases had Lymph node metastases, most of them were N1 and all of metastatic deposits in lymph nodes were positive for SATB2.
The correlation coefficient between SATB2 expression and PDC tumor grade was negative (-0.543), p value (<0.001). A highly statistically significant correlation between SATB2 expression and low tumor grade.
More than half of our studied CRC cases had Lymph node metastases, most of them were N1 and all of metastatic deposits in lymph nodes were positive for SATB2.
No statistically significant difference was found with regard to patients’ age group, group, tumor size, location, lymphovascular invasion, perineural invasion, omental deposits and tumor infiltrating lymphocytes.