الفهرس 
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Abstract
ABSTRACT
Background: Spinal anesthesia is the preferred method for elective cesarean sections due to considerable risks regarding airway management associated with physiological changes of pregnancy. Although it has been considered as a safe technique, spinal anesthesia has many side effects, including hypotension, bradycardia, nausea, and vomiting. Factors influencing the level and the intensity of block include the injected drug, the level of injection, the needle type, the patient position, and patient characteristics, such as age, height, weight, pregnancy, and spinal anatomy.
Objective: To evaluate the efficacy of different doses of granisetron, a 5-HT3 receptor inhibitors, on reducing the incidence of hypotension after subarachnoid block for cesarean section.
Patients and Methods: After obtaining approval from the Research Ethical Committee of Faculty of Medicine, Ain Shams University, and written informed consent this study was conducted in the operating theatres of Ain Shams University Hospitals.
Results: In our study we compared the effect of different doses of granisetron in reducing the hypotension occurring as a result of spinal anesthesia in parturients undergoing elective LSCS. The result of the study showed that compared to placebo group, there was a reduction in the degree of hypotension in group who was pre-medicated with IV grainsetron, and this reduction was more with increasing the dose of granisetron.
Conclusion: IV granisetron can be used as a pre-medication to reduce spinal anesthesia induced hypotension in parturients undergoing elective lower section cesarean section.