الفهرس | Only 14 pages are availabe for public view |
Abstract Conflicting results have been reported by numerous epidemiological studies investigating the association between Helicobacter pylori infection and inflammatory bowel disease (IBD). We aimed in this study to assess the possible association between H. pylori infection and IBD and its effects on disease progression. Design: Prospective observational study Setting: Specialized IBD care clinics at Alexandria University Student Hospital in northern Egypt, between March and June 2019. Participants: A total of 182 patients with IBD. Analysis and outcome measures: IBD participants were screened for H. pylori infection and clinically evaluated at the initial visit and bimonthly for 3 months to record any potential improvement/flare of the IBD condition. Results: Overall, 90 (49.5%) patients with IBD had evidence of H. pylori infection. The course of IBD did not significantly differ in association with H. pylori infection or IBD treatment strategy. Cox regression analysis revealed that patients aged 20–35 years (OR, 95% CI= 6.20 [1.74–22.12]) and 35– 55 years (OR, 95% CI = 557.9, [17.4–17922.8]), high socioeconomic status (OR 95% CI = 2.9 [1.11– 7.8]), daily consumption of fiber-rich food (OR, 95% CI = 5.1 [1.32–19.5]), occasional consumption of snacks between meals (OR, 95% CI = 2.8 [2.5–70.5]), and eating four meals per day (OR, 95% CI = 13.3 (1.0–7.7]) predicted IBD flare. In contrast, eating fruits and vegetables was strongly protective (OR, 95% CI = 0.001 (0.0002–0.02]). The probabilities of improvement of IBD symptoms after 12 weeks of follow-up were comparable, considering H. pylori infection status (0.793, H. pylori-negative vs. 0.778, H. pylori-positive) or IBD treatment option (0.811, conventional therapy vs. 0.750, biological therapy). Conclusion: The association between IBD and H. pylori infection is unresolved and must be further evaluated in the context of specific environmental exposures that influence the development or relapse of IBD. Keywords: Inflammatory Bowel Disease; Crohn’s disease; Ulcerative colitis; Helicobacter pylori. |