الفهرس | Only 14 pages are availabe for public view |
Abstract lycystic ovary syndrome (PCOS) is one of the most frequent endocrinopathies in women in reproductive age and in adolescence. The causes of PCOS are still being studied; there is an ongoing search for the genes responsible for the manifestations of the disease, and the clinical image is extraordinarily heterogeneous. There are gynecological and metabolic symptoms; all of them influence patient’s psychological condition and self-esteem (Kurek, 2017). In the etiopathogenesis of PCOS, the role of insulin resistance is emphasized as minimizing insulin resistance can play a significant role in controlling PCOS which was an indication for the attempts at using chromium III salts (Cr) in augmenting pharmacotherapy applied in patients (Moghetti, 2016). Chromium (III) is the synthetic salt form of Cr chloride which is the naturally occurring trivalent variety of chromium found in common food as broccoli, mushrooms and green beans. Picolinic acid may serve to improve chromium absorption (Yin and Phung, 2015). This study was designed to assess the effect of chromium salts in decreasing hirsutism scoring & Body Mass Index in polycystic ovary syndrome patients. This prospective randomized controlled clinical trial was conducted in Ain P Summary 105 Shams University Maternity Hospital on polycystic ovary syndrome patients attending gynecology or infertility outpatient clinics started from November 2020 to May 2021. It included 60 women (aged between 18-40 years) diagnosed as PCOS according to Rotterdam criteria with hyperandrogenism divided into 2 groups, group S (30 patients) receiving chromium (chromium picolinate, Mepaco) orally in a dose of 200microgram /day for 4 months’ duration, while group C (30 patients) received placebo (in the form of c retard capsules) with both groups received metformin with dose of 500mg oral tablets after main meal. In the current study we found that there were no significant differences between the two groups as regard age and marital status as P-value was 0.925, 0.284 respectively, there was insignificant difference between the two groups as regard duration of infertility, acne, acanthosis and average no. of cycles per year (p-value 0.915, 1.000, 1.000, 0.926 respectively). There were no significant differences between study groups as regard weight, BMI and hirsutism scoring at the start of the study as P-value 0.580, 0.648, 0.159 respectively. |