الفهرس 
A Pharmaceutical Study on a Non-Steroidal Anti-Inflammatory Drug
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Abstract
Pain is an unpleasant sensation and emotional experience associated with actual or potential tissue damage, or described in terms of such damage. Pain continues to present numerous challenges to the biopharmaceutical industry. The unmet medical need for new analgesic medicines is enormous and growing. There are key factors driving market growth include graying population, surging number of surgical procedures, and increasing number of cancer patients. Other factors include increasing popularity of the therapeutic benefits of effective pain treatment. Current analgesics only provide limited pain relief. There is clear need for novel, safe therapies that treat various types of pain. Lornoxicam, also known as chlortenoxicam, is a member of the oxicam family of NSAIDs, like Tenoxicam, Piroxicam, and Meloxicam but with extremely potent anti-inflammatory and analgesic activities reaches 10 folds more potent. It is widely used for the symptomatic treatment of pain and inflammation in patients with rheumatoid arthritis and osteoarthritis. Moreover, it showed great efficacy in various clinical trials in management of pre-operative and post-operative pain associated different surgeries. Like all other NSAIDs, lornoxicam mechanism of action is based on decreasing prostaglandin synthesis by inhibition of cyclooxygenase enzymes. However, lornoxicam has a relatively better gastrointestinal tolerability compared to the other NSAIDs which is superior in terms of lower side effects. Although lornoxicam shows considerable therapeutic benefits, its usefulness is limited by its distinct pH-dependent solubility characterized by poor solubility in low pH present in gastric medium. Thus, the aim of the current thesis was to ensure the rapid analgesic effect of lornoxicam after its oral administration and its dispersability in oral cavity, through modifying its solubility and dissolution rate also, its incorporation into different modified delivery systems. To achieve this aim, the work in this thesis is divided into three chapters