الفهرس 
Comparing modulatory effects of omega-3 versus aspirin in vasogenic brain changes in preeclampsia model
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Abstract
Preeclampsia (PE) is a multisystem maternal syndrome which characterized by utero-placental hypoperfusion and hypertension that induces a hypoxic state, and affect virtually every major organ system by causing endothelial dysfunction and systemic vasospasm thereby generating oxidative stress and promote production of proinflamatory mediators. On the other hand, omega-3 and aspirin have modulatory effect on arterial blood pressure (ABP), endothelium dysfunction and vasogenic brain changes in PE. Our present study aimed to further explore the possible anti-inflammatory and antioxidant role omega-3 and aspirin in the pathogenesis of preeclampsia. An experimental model of preeclampsia was induced by subcutaneous injection of N(})-nitro-L-arginine methyl ester (L- NAME) at a dose of 50mg/kg/day from day 7 to day 16 of pregnancy .Study groups included: normal control rats (non pregnant, control pregnant,control pregnant aspirin, control pregnant omega-3) and the main experimental groups of preeclampsia rats (PE control, PE omega-3 and PE aspirin).Aspirin and omega-3 were supplied in a dose of 5mg/kg orally and 144 mg/kg respectively using gastric tube from the first day of gestation G 0 to day 16