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Abstract The aim of the present study is to investigate the effect of some phytochemicals in germinated barley (GB) (Hordeum vulgare), germinated flaxseed(GFx) (Linum usitatissimum), and beetroot (BR)(Beta vulgaris) on rats, expermintnly suffered from cardiovascular failure (CVD) disease. Sixty adult male albino rats weighting 150- 200g were divided into ten groups, (n= 6). One group was kept as a (–ve) control group which fed on basel diet only, while the other nine groups were treated with adriamycin (ADM) for two days a week via IV injection, to induce CVD. Germinated Flaxseeds and barley and mixed with or without beetroot were added to basel diet in different levels (5, and 10%), respectively. The experiment lasted for 28 days. Obtained results indicated that treatment feeding the rats with basel diet suplmental with GB,GFX, BR in different levels (5% and 10%), respectively caused a significant (P ≤ 0.05) increase in weight gain, relative organs weights, and improve serum antioxidants, liver functions, kidney functions, decrease TC, TG, LDL, and VLDL levels. Therefore, it could be concluded that germinated barley and flaxseed with or without beetroot has the ability to improve the condition of blood vessels and reduce the risk of CVD through the reduction of harmful lipid profile and increasing the blood antioxidant levels. Histopathological investigation confirmed the enhancement effect of G B, G FX, BR of both of liver and heart status. Keywords: Germinated barley, Germinated flaxseed, Beetroot, CVD. |