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العنوان
Long-Non coding RNA As Diagnostic Tool in Diabetes-Related sub clinical Atherosclerosis /
المؤلف
Sakr, Mohamed El sayed.
هيئة الاعداد
باحث / محمد السيد محمد صقر
مشرف / نبيل عبدالفتاح الكفراوي
مشرف / شيماء كمال الدين زوين
مشرف / شيماء عبدالستار رفعت
الموضوع
Internal Medicine. Diabetes.
تاريخ النشر
2022.
عدد الصفحات
100 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الطب الباطني
تاريخ الإجازة
29/8/2022
مكان الإجازة
جامعة المنوفية - كلية الطب - الباطنة العامة
الفهرس
Only 14 pages are availabe for public view

from 105

from 105

Abstract

Type 2 diabetes (T2D) is a disease of high blood glucose (hyperglycemia) due to insulin action failure. About 463 million individuals have diabetes worldwide, with 90% of them Type 2 diabetes patients. The number is going to increase to 700 million affected people worldwide in 2045 . The increasing prevalence of diabetes worldwide is a burden, as most Type 2 diabetes patients will develop macrovascular and microvascular complications, which lead to various severe health problems and mortality.
Long non-coding RNAs (lncRNAs) are the RNA molecules with a size of more than 200 nucleotides and without the protein translation capacity. The biogenesis and functions of lncRNAs have been discussed extensively. LncRNAs are heterogeneous due to their genomic origins, in which they arise from the unconserved regions of the genome.
Cardiovascular disease remains the leading cause of mortality and morbidity worldwide. Cardiovascular disease is a broad term used to describe abnormalities affecting the heart and its associated circulatory system, such as atherosclerosis, myocardial ischemia/reperfusion injury and infarction, hypertension, and arrhythmias..
The etiology of atherosclerosis is as complex as the process responsible for its development. Atherosclerosis results from the combination of environmental risk factors including smoking, adiposity, blood pressure, blood cholesterol and diabetes mellitus
The aim of work of the current study was to analyze the correlation between long –noncoding RNA in asymptomatic Diabetic patients with subclinical atherosclerosis To elucidate this aim 312 patients were included in the study and categorized into two groups; control group which is not diagnosed with diabetes nor atherosclerosis (156 patients), cases group which is diagnosed with diabetes and atherosclerosis (156 Patients).