الفهرس 
Dysregulation of human beta-defensin-1 (hBD-1) in behcet{u2019}s disease : An association with pathophysiology of the disease
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Abstract
Background: Behçet’s disease (BD) is a multisystem inflammatory disease of unknown etiology. Beta-defensins are antimicrobial peptides involved in epithelial host defense. The purpose of this work is to explore whether beta-defensins might be involved in BD pathogenesis or not in in Egyptian patients. Methodology: This case control study included 40 BD patients fulfilling the criteria of the International Criteria for Behcet’s Disease (ICBD), compared to 40 age and sex matched healthy subjects. The -20G/A DEFB1 genotypes were determined by restriction fragment length polymorphism (RFLP) technique and systemic levels of plasma hBD-1 were measured using ELISA technique. Results: Plasma hBD-1 concentration was found to be significantly higher in patients than controls groups (p-value <0.001). No statistical significant difference was found between both groups regarding genotyping of -20G/A DEFB1 gene polymorphism (rs11362), allele frequency. Conclusion: The study findings suggest that hBD-1 is involved in BD pathophysiology, and may be used as a marker for BD and possibly a target for therapeutic intervention