الفهرس | Only 14 pages are availabe for public view |
Abstract Non-alcoholic fatty liver disease is becoming an important public health problem, Incidence is rising rapidly, and about 25% of global population is estimated to have NAFLD. Aim: Measuring L-carnitine in NAFLD patients and finding its correlation with NAFLD severity. Methods: The study included 80 participants, divided into 40 patients with NAFLD ultrasound grading and 40 healthy controls, labs including CBC, liver enzymes, lipid profile, TSH, insulin, fasting blood glucose and L-carnitine were done and HOMA IR score was calculated. Results: weight, BMI, WC, TSH, AST, ALT, cholesterol, LDL, TGS, Fasting blood glucose, insulin, HOMA IR were significantly higher in NAFLD group patients than control group. L-carnitine level significantly lower in NAFLD group patients than in healthy control and statistically significant negative correlation was found between L-carnitine and increasing fatty liver grade, BMI and HOMA IR. Increasing Fatty liver grade has statistically significant positive correlation with weight, WC, BMI, cholesterol, liver size, FBG, insulin and HOMA IR. Conclusion: Treatment of NAFLD patients using carnitine can be suggested, also HOMA IR is a significant predictor of NAFLD severity |