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العنوان
Assessment of immunological, parasitological and histopathological parameters after treatment with nitazoxanide and allium sativum (garlic) against murine cryptosporidiosis /
الناشر
Mona Yousry Mahmoud Osman ,
المؤلف
Mona Yousry Mahmoud Osman
هيئة الاعداد
باحث / Mona Yousry Mahmoud Osman
مشرف / Alyaa Ahmed Farid Ahmed
مشرف / Wajet Nabil
مشرف / Ibrahim Rabae Shalash
تاريخ النشر
2021
عدد الصفحات
70 P. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
علم الحيوان والطب البيطري
تاريخ الإجازة
14/11/2021
مكان الإجازة
جامعة القاهرة - كلية العلوم - Zoology
الفهرس
Only 14 pages are availabe for public view

from 85

from 85

Abstract

Cryptosporidium is a genus of apicomplexan parasitic alveolates that can cause a respiratory and gastrointestinal illness (cryptosporidiosis) that primarily involves watery diarrhea (intestinal cryptosporidiosis) with or without a persistent cough (respiratory cryptosporidiosis) in both immunocompetent and immunodeficient humans.The majority of chemotherapeutic agents used to treat parasitic disease are ineffective against cryptosporidiosis. Many compounds have been tested for their anti-cryptosporidial activity, but there is no effective therapy for preventing or treating cryptosporidiosis, particularly in immunocompromised individuals. Allium sativum has been used in many cultures for thousands of years in both food and medicine. The present study aimed to evaluate the efficacy of Allium sativum in treatment of cryptosporidiosis especially in immunosuppressed mice. Animals were divided into 8 groups (7 for each): group I: Immunocompetent control mice, group II: Immunosuppressed control mice, group III: Non-treated immunocompetent infected mice, group IV: Non-treated immunosuppressed infected mice, group V: Nitazoxanide treated immunocompetent infected mice, group VI: Nitazoxanide treated immunosuppressed infected mice, group VII: Allium sativum treated immunocompetent infected mice and group VIII: Allium sativum treated immunosuppressed infected mice. 0.25 mg/g/day dexamethasone was orally administrated for14consecutive days prior to infection with C. parvum oocysts.