الفهرس 
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Abstract
Low tumor oxygenation , also called hypoxia is a key source of concern for brain cancer patients because it encourages cancer cells to migrate (invade) into healthy brain tissue in attempt to escape the toxic environment. Tumor invasion not only makes surgery, radiation, and chemotherapy difficult, but it is also the main cause of death in individuals with brain cancer. Recognizing how hypoxia causes cancer cells to invade is critical for creating new and more effective treatments for this deadly illness.
The aim of the study was to evaluate serum levels of Caveolin-1 (CAV1), glucose transporter-1 (GLUT-1) and lactate dehydrogenase (LDH) pre and post radiation therapy in brain cancer patients.
This study included 80 subjects divided into two main groups:
group I: 30 healthy subjects age and sex matched as a control group.
group II: 50 brain cancer patients were subdivided into:
Glioblastoma subgroup: composed of 25 brain cancer patients.
Meningioma subgroup: composed of 25 Meningioma patients.
Our results showed that:
• CAV1 was significantly increased in all Brain tumor patients when comparing the values of cancer patients before and after radiotherapy to their correspondly control values. Furthermore, when compared to before radiotherapy, this biomarker increased dramatically after treatment especially, in Glioblastoma subgroup.
• Regarding GLUT-1, It was significantly higher in all brain cancer patients before and after radiotherapy when compared correspondly control levels. In addition, when compared to before treatment, this biomarker increased dramatically after radiotherapy especially, in Glioblastoma subgroup.
• LDH was significantly increased in all brain tumor patients when comparing the data of cancer patients to the correspondly control values before and after radiation, with significant increase in glioblastoma patients after radiotherapy. On the other hand, LDH was significantly decreased in meningioma patients following radiotherapy treatment compared to prior treatment .