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Abstract Summary Doppler ultrasound velocimetry of uteroplacental and fetal vessels has become established method of antenatal monitoring, cerebroplacental and cerebrouterine ratios have been studied to predict neonatal outcomes.In this study which include 110 women with preeclampsia admitted to Tanta university hospital, our aim was to assess the role of cerebroplacental ratio and cerebrouterine ratio in prediction of neonatal outcome in preeclamptic women.The current study showed that among patients with abnormal CP ratio (n = 36) 6 cases (16.7%) were small for gestational age, 28 cases (77.8%) had APGAR 1 min < 7, 16 cases (44.4%) had APGAR 5 min < 7, 25 cases (69.4%) admitted to NICU, and 5 cases (13.9%) suffered from Neonatal death, while among patients with abnormal CU ratio(n=48) 7 cases (14.6%) were small for gestational age, 27 cases (56.3%) had APGAR 1 min < 7, 25 cases (52.1%) had APGAR 5 min < 7, 36 cases (75%) admitted to NICU, and 7 cases (14.6%) suffered from Neonatal death, This shows that abnormal CP ratio and CU ratio are related to unfavorable pregnancy outcome. Abnormal CP ratio was statistically significant with unfavorable neonatal outcome except neonatal death (P=0.128) while abnormal CU ratio was more statistically significant with unfavorable neonatal outcome.In SGA, both CU and CP ratios had higher sensitivity and lower specificity, CP ratio was higher in PPV and accuracy than CU ratio while CU ratio was higher in NPV than CP ratio. In APGAR 1 < 7, CP ratio had higher sensitivity, PPV, specificity, NPV and accuracy than CU ratio. In APGAR 5 < 7, CU ratio had higher sensitivity and NPV than CP |