الفهرس 
Introduction and RationaleOnly 14 pages are availabe for public view
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Abstract
Breast cancer is the most commonly diagnosed cancer among women and one of the leading causes of cancer deaths among women worldwide. Breast cancer is a multifactorial disease and various risk factors contribute to its occurrence, resulting in variations in its incidence, mortality, and survival rates among different parts of the world.
In the current thesis we evaluated the immunohistochemical expression of Proline, glutamic acid and leucine-rich protein 1 (PELP1) in invasive breast carcinomas and its association with important clinical, histopathological and immunohistochemical parameters of breast carcinoma using immunohistochemical staining. This study was done at the pathology laboratory of Suez Canal University Hospital and included 82 cases of invasive breast carcinomas.
The clinical data, histopathological and immunohistochemical characteristics (age of patients at operation time, tumor size, tumor grade, status of axillary lymph nodal metastasis, lymphovascular permeation, perineural invasion, molecular subtypes and expression of ER, PR and HER-2) were collected from available medical records and pathology reports.
Our research involved 82 blocks of invasive breast carcinoma female cases, the age ranged from 35 to 80 years, with a mean of 54.52. PELP1 was positive in 80.49% of invasive breast carcinoma cases and negative in 19.51% of study cases. There was statistically significant association between PELP1 expression and older age (cases ≥ 50 years old), cases with luminal subtype and HER-2 enriched molecular subtypes of breast carcinoma. No statistically significant association was found between PELP1 expression and tumor grade, status of axillary lymph nodal metastasis, lymphovascular invasion, hormonal expression and triple negative molecular subtypes of breast carcinoma.