الفهرس 
Cross-Sectional AnatomyOnly 14 pages are availabe for public view
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Abstract
Summary Myocardial fibrosis is a fundamental process in the development of myocardial dysfunction in various cardiomyopathies, leading to myocardial remodeling and poor outcomes. The principal finding of this study is that noncontrast (native) T1 mapping has the potential to depict diffuse interstitial fibrosis in a variety of disease processes and to compare the potential utility of segmental quantification of myocardial fibrosis using native T1 mapping to late contrast enhancement imaging in different forms of cardiomyopathy. In our study 82 patients were included (72 cases as diseased and 10 cases as a control group), (72.2%male, 28% female) referred to national heart institute in the period from May2019 to May 2021. The control group was used to derive a specific reference range for native T1 values. All enrolled patients underwent cardiac MRI with a 1.5 T scanner (Siemens Healthcare). CMR scans consisted of localizing white /black blood images (axial, coronal, and sagittal), cine scans, native T1 mapping , and late gadolinium enhancement scans. The current study found that the native T1 values of patients with LGE were significantly higher than those of patients without LGE, as well as standard controls. Non-contrast T1 values in the mid LV septal segments were found to be the most significant ((1130.8579.79 ms Vs 1047.7442.74 ms; P= 0.001). In the current study ,T1 values were also substantially higher than usual in segments unaffected by LGE (P value 0.01) in both the HCM and DCM groups. A receiver operating characteristic (ROC) analysis revealed the required cutoff value of 1070 ms for detecting myocardial fibrosis with a sensitivity 66% and specificity of 68 %. T1-mapping demonstrated excellent diagnostic performance with a significantly larger area-under-the-curve (AUC= 0.72) compared to LGE –CMR. .