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Abstract Toxoplasma gondii is an obligate intracellular protozoon, which affects about 30% of the population all over the world. Although it is considered to be one of the most widespread disease agents, clinical diseases caused by this parasite are not common, since the majority of infected persons remain asymptomatic latent infection. Toxoplasma is a zoonotic infection, where the definite host belongs to the feline family, whereas humans and other warm-blooded animal are intermediate hosts. It is considered to be one the opportunistic parasites and can be transmitted by a variety of modes. Toxoplasma gondii oocysts shed by the feline host can be acquired by ingestion of contaminated food and water. In addition, meat can also constitute a source of infection, if it contains tissue cysts. Other infection routes include organ transplantation, blood transfusion and congenital transmission from mother to fetus. Toxoplasmosis exists mainly in its latent form, with reactivation of infection occurring in immunecompromised persons, since Toxoplasma gondii is an opportunistic parasite. Acute toxoplasmosis is often underdiagnosed due to the ambiguity of clinical symptoms such as lymphadenits and sore throat. Congenital toxoplasmosis presents with more serious ocular and neurological disorders. Since Toxoplasma gondii is an intracellular parasite, it reaches many body systems and has a wide range of effects on host physiological functions, such as endocrine balance. An example for hormonal alterations in seropositive toxoplasmosis patients is the activation of hypothalamic pituitary adrenal (HPA) axis and subsequently, an increase in glucocorticoid concentration. In addition, elevated testosterone, prolactin levels have been found in Toxoplasma seropositive patients. Prolactin which is a hormone released from the anterior pituitary (under the inhibitory control of dopamine) plays a major role in the lactation, regulation of reproductive functions, growth. Prolactin receptors are well expressed in the adrenal glands. In cases of hyperprolactinemia, adrenal androgens are secreted in an increased manner and contribute to the rapid formation of acne vulgaris and progress of androgenic alopecia. This wide spectrum of physiological alterations observed concomitantly with toxoplasmosis suggests the possible involvement of this protozoal infection in multifactorial disorders related to endocrine alterations. Such as acne vulgaris and androgenic alopecia. Acne vulgaris is an inflammatory skin condition appearing in adolescence and may continue to older age groups. Sebum production, which plays a pivotal role in acne formation, is under hormonal control, since sebaceous glands harbor androgen receptors for testosterone. Since the skin displays its own peripheral HPA axis. Sebocytes express corticotrophin releasing hormone (CRH) receptors and CRH has been found to promote lipogenesis by these cells |