الفهرس | Only 14 pages are availabe for public view |
Abstract The present thesis consists of the following chapters: Chapter 1: An introduction about Alzheimer’s disease, protease enzyme, β-secretase and literature review. Chapter 2: Our rationale is based on design of novel compounds as β-secretase inhibitors using isocytosine, indole and benzimidazoles scaffolds. Chapter 3: Design of novel compounds, biological evaluation and docking studies. Chapter 4: Synthesis and characterization of 49 intermediates and 33 final compounds. References: A list of 169 references used according to their order in thesis. Appendix: The 13C- NMR and/or 1H-NMR of all the synthesized compounds for this work |